Category Archives: Theory and Practice of Medicine

Diagnostic delay in cancer: a complex landscape

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People from India

There is a good rational to assume that the smaller a tumor  the better the outcome. However, there are several  variables and prognostic factors involved in the clinical evolution of a patient, not only time. The process of diagnostic in cancer have been artificially divided in different segments related to the patient, the appointment with a doctor and the pattern of referral. In all these models the physician looks like the perfect machine prepared for a perfect diagnosis….

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NUT Midline Carcinoma (NMC): a new disease

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Chance or a clever clinical observation is at the origin of the discovery of new clinical entities. A cluster of opportunistic pulmonary infections in young people was associated with HIV infection. Diethylstilbestrol taken by women was related to vaginal cancer in their daughters. NUT Midline carcinoma (the name coming from the rearrangements of the gene NUT) has been defined as a new clinical entity after the observation of several cases with undifferentiated carcinoma located in the midline, from the nasopharyngeal area to the mediastinum…

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Molecular Oncology: a step further in diagnosis linked to treatment

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Trogir, Croatia

Diagnosis in Medical Oncology is facing a revolution. Morphology and a limited set of cellular markers are the keystone of the diagnosis and at the end, we will classify a lung cancer in two categories, non-small cell lung cancer or small cell cancer, a colorectal cancer in just a category, breast cancer could be divided based on morphology in ductal or lobular and we can continue with the rest of the tumors. But the landscape is evolving…

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Bone findings in cancer patients mimicking metastases (2)

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Pastelaria, Portugal

Bone lesions in cancer patients must be identified as malignant or benign due to the important prognostic and therapeutic implications.  Benign bone fi ndings detected during the staging period and follow-up are common in cancer patients.  The knowledge of these entities in this context could help to reduce the possibility of a cognitive bias.

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